کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2501968 1557367 2014 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Liposome encapsulation of curcumin: Physico-chemical characterizations and effects on MCF7 cancer cell proliferation
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی علوم دارویی
پیش نمایش صفحه اول مقاله
Liposome encapsulation of curcumin: Physico-chemical characterizations and effects on MCF7 cancer cell proliferation
چکیده انگلیسی

The role of curcumin (diferuloylmethane), for cancer treatment has been an area of growing interest. However, due to its low absorption, the poor bioavailability of curcumin limits its clinical use. In this study, we reported an approach of encapsulation a curcumin by nanoliposome to achieve an improved bioavailability of a poorly absorbed hydrophobic compound. We demonstrated that liposomal preparations to deliver curcumin increase its bioavailability. Liposomes composed of salmon's lecithin also improved curcumin bioavailability compared to those constituted of rapeseed and soya lecithins. A real-time label-free cell analysis system based on real-time cell impedance monitoring was used to investigate the in vitro cytotoxicity of liposomal preparations.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Pharmaceutics - Volume 461, Issues 1–2, 30 January 2014, Pages 519–528
نویسندگان
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