کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2502347 1557378 2013 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Consolidation trend design based on Young's modulus of clarithromycin single crystals
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی علوم دارویی
پیش نمایش صفحه اول مقاله
Consolidation trend design based on Young's modulus of clarithromycin single crystals
چکیده انگلیسی

The key aim of this study was to determine single mechanical properties of clarithromycin polymorphic forms in order to select some of them as more suitable for the tableting process. For this purpose, AFM single-point nanoindentation was used. The Young's moduli of clarithromycin polymorphs were substantially different, which was consistent with the structural variations in their packing motifs. The presence of the adjacent layers, which can easily slide over each other due to the low energy barrier (the lowest Young's modulus was 0.25 GPa) resulted in better bulk compressibility (the highest Heckel coefficient) of clarithromycin Form I. We also addressed the importance of tip geometry screening because the stress during the force mode often results in tip apex fracture. Even the initial manufacture of the diamond-coated tips can result in defects such as double-apex tips.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Pharmaceutics - Volume 454, Issue 1, 15 September 2013, Pages 324–332
نویسندگان
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