کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2502415 | 1557380 | 2013 | 32 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Manufacturing of solid dispersions of poorly water soluble drugs by spray drying: Formulation and process considerations Manufacturing of solid dispersions of poorly water soluble drugs by spray drying: Formulation and process considerations](/preview/png/2502415.png)
Spray drying is an efficient technology for solid dispersion manufacturing since it allows extreme rapid solvent evaporation leading to fast transformation of an API-carrier solution to solid API-carrier particles. Solvent evaporation kinetics certainly contribute to formation of amorphous solid dispersions, but also other factors like the interplay between the API, carrier and solvent, the solution state of the API, formulation parameters (e.g. feed concentration or solvent type) and process parameters (e.g. drying gas flow rate or solution spray rate) will influence the final physical structure of the obtained solid dispersion particles. This review presents an overview of the interplay between manufacturing process, formulation parameters, physical structure, and performance of the solid dispersions with respect to stability and drug release characteristics.
Figure optionsDownload high-quality image (408 K)Download as PowerPoint slide
Journal: International Journal of Pharmaceutics - Volume 453, Issue 1, 30 August 2013, Pages 253–284