کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2503224 1557429 2011 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Evaluation of the physicochemical characteristics of crospovidone that influence solid dispersion preparation
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی علوم دارویی
پیش نمایش صفحه اول مقاله
Evaluation of the physicochemical characteristics of crospovidone that influence solid dispersion preparation
چکیده انگلیسی

A solid dispersion (SD) powder of indomethacin (IM) with crospovidone (CrosPVP) shows useful characteristics for manufacturing dosage forms. Four types of commercial CroPVP, Polyplasdone® XL (XL) used as the initial carrier, Polyplasdone® XL10 and INF-10® manufactured by milling XL, and Kollidon® CL (CL) marketed by another company, were compared. The limit of the IM–CrosPVP weight ratio with which an SD can be prepared (maximum IM content) was calculated on the basis of the heat of fusion of physical mixtures of IM and CrosPVP with various weight ratios. When Polyplasdone®s were used, the maximum IM content increased with the specific surface area of the CrosPVP. When CL was used, however, it was about half of that obtained with XL, even though the difference between XL and CL was not observed in the physicochemical characteristics (particle size, specific surface area, flowability, glass transition temperature, IR spectra, and solid state NMR spectra). As determined by pore size distribution measurement, the volume of pore of which size is larger than the particle size of IM was less in CL than in XL. Therefore, the effective surface area of CrosPVP that comes in contact with IM is important for the preparation of the SD.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Pharmaceutics - Volume 413, Issues 1–2, 15 July 2011, Pages 119–125
نویسندگان
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