کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2503745 | 1557436 | 2011 | 6 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Chemotherapy with hybrid liposomes for acute lymphatic leukemia leading to apoptosis in vivo Chemotherapy with hybrid liposomes for acute lymphatic leukemia leading to apoptosis in vivo](/preview/png/2503745.png)
Hybrid liposomes (HL) composed of 95 mol% l-α-dimyristoylphosphatidylcholine (DMPC) and 5 mol% polyoxyethylene (25) dodecyl ether (C12(EO)25) were prepared by sonication. A clear solutions of HL-25 having hydrodynamic diameter of about 50 nm could be maintained over 3 weeks. Remarkable reduction of tumor volume in model mice of acute lymphatic leukemia (ALL) intravenously treated with HL-25 without drugs after the subcutaneously inoculation of human ALL (MOLT-4) cells was verified in vivo. Induction of apoptosis in tumor of model mice of ALL treated with HL-25 was observed in micrographs on the basis of TUNEL method. Remarkable decrease of the ascites in ALL model mice treated with HL-25 was observed. It is noteworthy that prolonged survival (>400%) was obtained in model mice of ALL after the treatment with HL-25 without drugs.
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Journal: International Journal of Pharmaceutics - Volume 406, Issues 1–2, 15 March 2011, Pages 173–178