کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2503806 1557442 2010 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Antitumor activity of quaternized chitosan-based electrospun implants against Graffi myeloid tumor
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی علوم دارویی
پیش نمایش صفحه اول مقاله
Antitumor activity of quaternized chitosan-based electrospun implants against Graffi myeloid tumor
چکیده انگلیسی

Nanofibrous implants containing quaternized chitosan (QCh), poly(l-lactide-co-d,l-lactide) (coPLA), and the antitumor drug doxorubicin (DOX) were fabricated by electrospinning. The surface chemical composition and the morphology of the implants were characterized by XPS and SEM. In vitro cell viability studies demonstrated that QCh- and DOX-based implants exhibited high cytotoxicity against Graffi tumor cells. The implants efficiently inhibited the growth of Graffi tumor in hamsters with minimum weight loss. Insertion of QCh/coPLA/DOX implants in the place of removed tumor led to an increase in the animal survival rate and to a decrease in the percentage of recurrences.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Pharmaceutics - Volume 400, Issues 1–2, 15 November 2010, Pages 221–233
نویسندگان
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