کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2504536 1557457 2010 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Non-viral gene delivery carrier and its three-dimensional transfection system
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی علوم دارویی
پیش نمایش صفحه اول مقاله
Non-viral gene delivery carrier and its three-dimensional transfection system
چکیده انگلیسی

An increasing number of non-viral vectors are being developed for the use of gene delivery nowadays, among which cationic polymers and lipoplexes receive most attention. Most of these researches are focused on how to increase the transfection efficiency of non-viral vectors as well as the reduction of toxicity. In this review, we go over new strategies to reduce the toxicity of cationic polyplexes such as poly(ethylene-imine) and the construction of highly effective gene transfer vector lipoplexes. In addition, since transformation of gene expression system from two-dimensional (2D) substrate to 3D scaffold triggers far better transfection efficiency, the non-viral vectors applied in 3D transfection system have also been reviewed.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Pharmaceutics - Volume 386, Issues 1–2, 15 February 2010, Pages 232–242
نویسندگان
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