کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2504890 1557472 2009 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Formulation, stability and degradation kinetics of intravenous cinnarizine lipid emulsion
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی علوم دارویی
پیش نمایش صفحه اول مقاله
Formulation, stability and degradation kinetics of intravenous cinnarizine lipid emulsion
چکیده انگلیسی

Cinnarizine was loaded in the lipid emulsion to develop an intravenous formulation with good physical and chemical stability. High-pressure homogenization was used to prepare the lipid emulsion. The factors influencing the stability of cinnarizine lipid emulsion, such as different drug loading methods, pH, temperature, sterilization methods and sterilization time were monitored by high-performance liquid chromatograph. The degradation of cinnarizine in aqueous solution and lipid emulsion both followed apparent first-order kinetics. A possible degradation mechanism was postulated by the bell-shaped pH-rate profile of cinnarizine. Localization of the drug in the interfacial lecithin layer significantly improved the chemical stability of cinnarizine and its stabilizing mechanism was thoroughly discussed and proved. The activation energy of cinnarizine in lipid emulsion was calculated to be 51.27 kJ/mol which was similar to that in aqueous solution. This indicates that the stabilizing effect of the drug carrier on cinnarizine was not an alteration of the degradation reaction. In addition, shelf-life of cinnarizine in lipid emulsion was estimated to be 1471.6 days at 4 °C, which is much longer compared with 19.8 days in aqueous solution. The final products were stable enough to resist a 121 °C rotating steam sterilization for 15 min.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Pharmaceutics - Volume 373, Issues 1–2, 21 May 2009, Pages 147–155
نویسندگان
, , , ,