کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2505857 1557502 2007 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Potentialities of silica/alginate nanoparticles as Hybrid Magnetic Carriers
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی علوم دارویی
پیش نمایش صفحه اول مقاله
Potentialities of silica/alginate nanoparticles as Hybrid Magnetic Carriers
چکیده انگلیسی

The possibility to associate traditional bio-organic capsules, such as polymer nanoparticles or liposomes, with silica has been recently demonstrated, opening the route to the design of novel nanocomposites that exhibit promising properties as drug carriers. In this context, we describe here the elaboration of silica/alginate nanoparticles incorporating magnetic iron oxide colloids and fluorescent carboxy-fluoroscein. These nanocomposites were characterized by electron microscopy, X-ray diffraction and magnetic measurements. The release of the fluorophore was investigated in vitro and was demonstrated to occur in 3T3 fibroblast cells. Further grafting of organic moieties on particle surface is also described. These data suggest that hybrid nanoparticles are flexible platforms for the developments of multi-functional bio-capsules.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Pharmaceutics - Volume 344, Issues 1–2, 1 November 2007, Pages 128–134
نویسندگان
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