l-Nucleoside enantiomers as antivirals drugs: A mini-review

The discovery that some nucleoside analogues endowed with the unnatural l-configuration can possess biological activities has been a significant breakthrough in antiviral chemotherapy. In this regard, lamivudine (3TC) was the first l-nucleoside enantiomer approved against HIV and HBV, and several other l-nucleosides are currently under clinical development as antiviral agents