کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2514896 | 1118491 | 2006 | 7 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Therapeutic and preventive properties of quercetin in experimental arthritis correlate with decreased macrophage inflammatory mediators Therapeutic and preventive properties of quercetin in experimental arthritis correlate with decreased macrophage inflammatory mediators](/preview/png/2514896.png)
Pentahydroxyflavone dihydrate, quercetin (QU) is one of common flavonols biosynthesized by plants and has been suggested to modulate inflammatory responses in various models. In the present study, we investigated in vivo effects of oral or intra-cutaneous QU in chronic rat adjuvant-induced arthritis (AA). Growth delay and arthritic scores were evaluated daily after AA induction in Lewis rats. Oral administration of QU (5× 160 mg/kg) to arthritic rats resulted in a clear decrease of clinical signs compared to untreated controls. Intra-cutaneous injections of lower doses (5× 60 mg/kg) of QU gave similar anti-arthritic effects, while 5× 30 mg/kg concentrations were inefficient in this respect. Finally, injection of relatively low QU doses (5× 30 mg/kg) prior to AA induction significantly reduced arthritis signs. As QU was suggested to inhibit macrophage-derived cytokines and nitric oxide (NO), we then analyzed macrophage response ex vivo. Anti-arthritic effects of QU correlated with significant decrease of inflammatory mediators produced by peritoneal macrophages, ex vivo and in vitro. These data indicate that QU is a potential anti-inflammatory therapeutic and preventive agent targeting the inflammatory response of macrophages.
Journal: Biochemical Pharmacology - Volume 72, Issue 10, 15 November 2006, Pages 1304–1310