کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2542147 | 1122690 | 2006 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Modulation of neutrophil apoptosis by β-amyloid proteins
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
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چکیده انگلیسی
This study examined the effect of amyloid β peptide (Aβ) and the secretase inhibitors of amyloid precursor proteins (APP) on the spontaneous apoptosis of neutrophils. Aβ(1-40) decreased the apoptotic rate of neutrophils. The delayed apoptosis by Aβ was not blocked by pertussis toxin and N-formyl peptide receptor-like 1 antagonistic peptide, WRWWWW. The inhibitors of phoshoinositide 3-kinase (LY294002), phospholipase C (U73122), or Ca++-dependent protein kinase C (Go6976) abrogated the anti-apoptotic effect of Aβ on neutrophils. Moreover, the Aβ-induced delay of apoptosis was inhibited by a calcium chelator, BAPTA/AM. The amount of the APP protein was reduced in the cultured neutrophils and the APP level in the Aβ or pancaspase-treated neutrophils was lower than that in the cultured neutrophils. However, the reduction in APP level was recovered after treating them with the secretase inhibitors or anti-Fas antibody. The exogenous addition of cell permeable β- and γ-secretase inhibitors resulted in an increase in the rate of the apoptosis. The regulation of neutrophil apoptosis by the addition of Aβ and secretase inhibitors occurred via the caspase -8, -9, -3, and mitochondrial-dependent pathways. This suggests that the intracellular β-amyloid proteins play a role as regulating factor of neutrophil survival and that Aβ-induced delay of apoptosis is mediated by other receptors rather than a seven-transmembrane G protein-coupled receptor(s).
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Immunopharmacology - Volume 6, Issue 7, July 2006, Pages 1061-1069
Journal: International Immunopharmacology - Volume 6, Issue 7, July 2006, Pages 1061-1069
نویسندگان
Hae-Young Park, Joo-In Park, Dae-Won Baek, Sun-Young Lee, Min-Jung Lee, Jun-O Jin, Ja-Woong Kim, Young-Seoub Hong, Yong-Hwan Lee, Jong-Young Kwak,