کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2547706 | 1124066 | 2006 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Antimicrobial, wound healing and antioxidant activity of Plagiochasma appendiculatum Lehm. et Lind.
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
LPOPlagiochasma appendiculatumMDAPAESTZTBARSMICGSHCATROS - ROSAntioxidant - آنتی اکسیدانstreptozotocin - استرپتوزوتوسینWound Healing - التیام زخمPhytochemical constituents - ترکیبات فیتوشیمیاییMinimum inhibitory concentration - حداقل غلظت مهاریSOD - سدSuperoxide dismutase - سوکسوکس دیسموتازAntimicrobial activity - فعالیت ضدمیکروبیmalondialdehyde - مالون دی آلدهیدthiobarbituric acid reactive substances - مواد واکنش پذیر اسید تیوباربیتوریکLipid peroxidation - پراکسیداسیون لیپیدCatalase - کاتالازGlutathione - گلوتاتیونReactive oxygen species - گونههای فعال اکسیژن
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
داروشناسی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Plagiochasma appendiculatum (Aytoniaceae) of the order Marchantiales is widely used in the form of paste ethnomedicinally by Gaddi tribe in Kangra valley for treating skin diseases. In this context, antimicrobical potential of Plagiochasma appendiculatum against a wide range of microorganisms was studied. To validate the ethnotherapeutic claims of the plant in skin diseases, wound healing activity was studied, besides antioxidant activity to understand the mechanism of wound healing activity. The plant (alchoholic and aqueous extract) showed significant antibacterial and antifungal activity against almost all the organisms: Micrococcus luteus, Bacillus subtilis, Bacillus cereus, Staphylococcus aureus, Streptococcus pneumoniae, Enterobacter aerogenes, Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Pseudomonas aeruginosa, Salmonella typhimurium, and eight fungi Candida albicans and Cryptococcus albidus-dimorphic fungi, Trichophyton rubrum-dermatophyte fungi, Aspergillus niger, Aspergillus flavus, Aspergillus spinulosus, Aspergillus terreus and Aspergillus nidulans-systemic fungi, with especially good activity against the dermatophyte (Trichophyton rubrum) and some infectious bacteria (Escherichia coli, Proteus mirabilis and Salmonella typhimurium) with an MIC of 2.5 μg/disc. The results show that Plagiochasma appendiculatum extract has potent wound healing capacity as evident from the wound contraction and increased tensile strength. The results also indicated that Plagiochasma appendiculatum extract possesses potent antioxidant activity by inhibiting lipid peroxidation and increase in the superoxide dismutase (SOD) and Catalase activity.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Ethnopharmacology - Volume 107, Issue 1, 11 August 2006, Pages 67-72
Journal: Journal of Ethnopharmacology - Volume 107, Issue 1, 11 August 2006, Pages 67-72
نویسندگان
Meenakshi Singh, Raghavan Govindarajan, Virendra Nath, Ajay Kumar Singh Rawat, Shanta Mehrotra,