کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2553082 | 1560714 | 2009 | 7 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Chamomile, a novel and selective COX-2 inhibitor with anti-inflammatory activity Chamomile, a novel and selective COX-2 inhibitor with anti-inflammatory activity](/preview/png/2553082.png)
AimsInducible cyclooxygenase (COX-2) has been implicated in the process of inflammation and carcinogenesis. Chamomile has long been used in traditional medicine for the treatment of inflammatory diseases. In this study we aimed to investigate whether chamomile interferes with the COX-2 pathway.Main methodsWe used lipopolysaccharide (LPS)-activated RAW 264.7 macrophages as an in vitro model for our studies.Key findingsChamomile treatment inhibited the release of LPS-induced prostaglandin E(2) in RAW 264.7 macrophages. This effect was found to be due to inhibition of COX-2 enzyme activity by chamomile. In addition, chamomile caused reduction in LPS-induced COX-2 mRNA and protein expression, without affecting COX-1 expression. The non-steroidal anti-inflammatory drug, sulindac and a specific COX-2 inhibitor, NS398, were shown to act similarly in LPS-activated RAW 264.7 cells. Our data suggest that chamomile works by a mechanism of action similar to that attributed to non-steroidal anti-inflammatory drugs.SignificanceThese findings add a novel aspect to the biological profile of chamomile which might be important for understanding the usefulness of aqueous chamomile extract in the form of tea in preventing inflammation and cancer.
Journal: Life Sciences - Volume 85, Issues 19–20, 4 November 2009, Pages 663–669