کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2555810 | 1125133 | 2005 | 14 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Utilization of in vivo ultrafiltration in biomedical research and clinical applications Utilization of in vivo ultrafiltration in biomedical research and clinical applications](/preview/png/2555810.png)
Ultrafiltration (UF) is a filtrate selection method with a wide range of biomedical and clinical applications, including detoxification of blood in hemodialysis and peritoneal dialysis. New is, however, the use of UF as a convenient in vivo sampling method that, for example, has been used in diabetics. Ultrafiltration avoids complicated and time-consuming recovery calculations that are necessary when using in vivo microdialysis, as recoveries of low molecular weight molecules are near 100%. The subcutaneously or intravenously placed UF probes have been studied for off-line sample analysis and for continuous on-line monitoring, in a wide variety of species, including dogs, rats, pigs and humans.This review discusses the potential of in vivo UF as a continuous tissue sampling technique in clinical research areas, and in several major biomedical applications including glucose and lactate monitoring and drug kinetic studies.
Journal: Life Sciences - Volume 73, Issue 16, 5 September 2003, Pages 2005–2018