کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2565707 | 1128065 | 2008 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Adiponectin multimer distribution, not absolute amount of plasma, correlates with depression severity in healthy elderly subjects
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کلمات کلیدی
HbA1cFPGHMWMMWLMWadiponectin - آدیپونکتینElderly subjects - افراد سالمندDepression - افسردگیcardiovascular disease - بیماری قلب و عروقیCVD - رسوب دهی شیمیایی بخار body mass index - شاخص توده بدنBMI - شاخص توده بدنیBlood pressure - فشارخونFasting plasma glucose - قند خون ناشتاInsulin resistance - مقاومت به انسولینHemoglobin A1c - هموگلوبین A1chigh molecular weight - وزن مولکولی بالاlow molecular weight - وزن مولکولی کم
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
روانپزشکی بیولوژیکی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Adiponectin multimer distribution, not absolute amount of plasma, correlates with depression severity in healthy elderly subjects Adiponectin multimer distribution, not absolute amount of plasma, correlates with depression severity in healthy elderly subjects](/preview/png/2565707.png)
چکیده انگلیسی
Adiponectin is an adipocyte-specific secretory protein that circulates in serum as three oligomeric complexes known as the high, medium and low molecular weight form (HMW, MMW and LMW). HMW adiponectin has been suggested to be a better predictor of metabolic variables, and it was recently reported that the ratio of HMW to total adiponectin or to LMW, not the absolute amount of plasma adiponectin, might be crucial in determining insulin sensitivity. Insulin resistance (IR) is considered to be a primary component of vascular risk factors. Although the association of depression with atherosclerotic vascular diseases has been well documented, the contribution of IR to the evolution and progression of depression-associated vascular morbidity and mortality remains unknown. The current preliminary study showed that the ratio of HMW to total adiponectin or to LMW, not the absolute amount of plasma adiponectin, was negatively associated with depression severity in healthy elderly subjects without metabolic syndrome. This pilot study supports a promising role of adiponectin multimer distribution for clarifying the pathophysiological mechanism by which depression is associated with increased risk for IR, leading to cardiovascular disease, metabolic syndrome or type 2 diabetes.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Progress in Neuro-Psychopharmacology and Biological Psychiatry - Volume 32, Issue 1, 1 January 2008, Pages 124-127
Journal: Progress in Neuro-Psychopharmacology and Biological Psychiatry - Volume 32, Issue 1, 1 January 2008, Pages 124-127
نویسندگان
Kosuke Narita, Tetsuhito Murata, Toshihiko Hamada, Tetsuya Takahashi, Hirotaka Kosaka, Satoru Sudo, Kimiko Mizukami, Haruyoshi Yoshida, Yuji Wada,