کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2566070 | 1128073 | 2008 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Is there protective haplotype of dysbindin gene (DTNBP1) 3 polymorphisms for major depressive disorder
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کلمات کلیدی
MDDHWEDSM-IVDTNBP1DPCodds ratio.Major depressive disorder - اختلال افسردگی عمدهgamma-aminobutyric acid - اسید گاما آمینو بوتیریکMajor depression - افسردگی شدیدExpectation Maximization - به حداکثر رساندن انتظاراتHardy–Weinberg equilibrium - تعادل هاردی-وینبرگLinkage disequilibrium - عدم تعادل پیوستگیconfidence interval - فاصله اطمینانHaplotype - هاپلوتیپGABA - گابا
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
روانپزشکی بیولوژیکی
پیش نمایش صفحه اول مقاله
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چکیده انگلیسی
Dysbindin gene has been repeatedly associated with psychiatric disorders and schizophrenia in particular. This study aimed to investigate the variants of dysbindin gene in major depressive disorder (MDD). One hundred and eighty eight patients with MDD and 350 controls were investigated for 4 variants within the dysbindin gene (rs3213207 A/G, rs1011313 C/T, rs760761 C/T, and rs2619522 A/C). Haplotype analyses revealed a significant association with MDD (p = 0.0007, protective A-C-T-A and A-C-C-C haplotypes), in particular the effect was due to the rs760761 (C/T) and rs2619522 (A/C) haplotype (p = 0.000026). These results suggest a protective effect of some dysbindin gene haplotypes on the development of MDD. Coupled with previous findings on schizophrenia, our finding suggests that dysbindin gene variants may have a role in the susceptibility to MDD. Adequately powered further studies in different ethnic groups are warranted.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Progress in Neuro-Psychopharmacology and Biological Psychiatry - Volume 32, Issue 2, 15 February 2008, Pages 375-379
Journal: Progress in Neuro-Psychopharmacology and Biological Psychiatry - Volume 32, Issue 2, 15 February 2008, Pages 375-379
نویسندگان
Jung-Jin Kim, Laura Mandelli, Chi-Un Pae, Diana De Ronchi, Tae-Youn Jun, Chul Lee, In-Ho Paik, Ashwin A. Patkar, David Steffens, Alessandro Serretti, Changsu Han,