کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2566124 | 1128074 | 2007 | 6 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Influence of chronic cocaine treatment and sleep deprivation on sexual behavior and neurogenesis of the male rat Influence of chronic cocaine treatment and sleep deprivation on sexual behavior and neurogenesis of the male rat](/preview/png/2566124.png)
The present study investigated the influence of chronic cocaine treatment on genital reflexes associated with paradoxical sleep deprivation (PSD), and possible alterations in hippocampus neurogenesis of the male rat. At 21 days of age, the rats were distributed into two groups and injected with saline or cocaine (7 mg/kg, three times a week for 12 weeks). At age 90 days, they were submitted to a four-day period of PSD (PSD groups) or maintained in home-cages (control groups), challenged with saline or cocaine administration, and placed in observation cages to assess genital reflexes. Two additional groups were used to quantify neurogenesis. PSD rats treated chronically with cocaine and challenged with saline did not differ from their respective control groups. The association of PSD with cocaine potentiated penile erection (PE) when compared to PSD-saline (saline challenged) rats, and these effects were similar to those observed in long-term cocaine treated rats. The bromodeoxyuridine (BrdU) assay indicated a reduction in BrdU-positive cells in the adult hippocampus after chronic cocaine treatment. These findings show that long-term cocaine treatment from brain development through adulthood had a marked effect on sexual responses and neuronal proliferation.
Journal: Progress in Neuro-Psychopharmacology and Biological Psychiatry - Volume 31, Issue 6, 15 August 2007, Pages 1224–1229