کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2566137 | 1128074 | 2007 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Veratrine blocks the lamotrigine-induced swimming increase and immobility decrease in the modified forced swimming test
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کلمات کلیدی
5-HTLTGFSTNMDAN-methyl-d-aspartateNa+ - Na +SAL - WILLForced swimming test - آزمون اجباری شناanalysis of variance - تحلیل واریانسANOVA - تحلیل واریانس Analysis of varianceSaline - سالینSodium - سدیم Serotonin - سروتونینAntidepressant - ضدافسردگیLamotrigine - لاموتریژینRat - موش صحراییnoradrenaline - نورآدرنالین Nitric oxide - نیتریک اکسیدVeratrine - واترینVera - وراVehicle - وسیله نقلیه
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
روانپزشکی بیولوژیکی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Lamotrigine exhibits an anti-immobility effect in the modified forced swimming test, increasing swimming and climbing, behaviors that are related to serotonergic and noradrenergic effects, respectively. However, these effects could be secondary to lamotrigine blockade of Na+ sensitive channel. Thus, this study investigated the influence of veratrine (0.1Â mg/kg, ip, 10Â min before each lamotrigine administration), an Na+ channel activator, in the effect of lamotrigine (20Â mg/kg, ip, 24, 5, 1Â h before the test session) in the modified forced swimming test. Veratrine pre-treatment blocked lamotrigine-induced immobility decrease and swimming increase but it did not change the effect of lamotrigine on climbing. These results suggest that the serotonergic effect of lamotrigine in the modified forced swimming test is dependent on Na+ voltage sensitive channel blockade, whereas its noradrenergic effect is not.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Progress in Neuro-Psychopharmacology and Biological Psychiatry - Volume 31, Issue 6, 15 August 2007, Pages 1307-1311
Journal: Progress in Neuro-Psychopharmacology and Biological Psychiatry - Volume 31, Issue 6, 15 August 2007, Pages 1307-1311
نویسندگان
F.T. Codagnone, F.T. Consoni, A.L.S. Rodrigues, M.A.B.F. Vital, R. Andreatini,