کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2566172 | 1128075 | 2007 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Olanzapine withdrawal/discontinuation-induced hyperthermia in rats
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
روانپزشکی بیولوژیکی
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چکیده انگلیسی
In female rats olanzapine (4Â mg/kg b.i.d., i.p.) induced acute hypothermia, followed by very rapid full tolerance. With more prolonged treatment (over >Â 10Â days) the hypothermic effect of olanzapine was reinstated. Subsequent withdrawal after 18Â days of treatment induced very rapid onset (within 1Â day) hyperthermia, which was time limited, dissipating completely over 3-4Â days. These findings are similar to previous findings with clozapine [Goudie A Smith J Robertson A Cavanagh C (1999). Clozapine as a drug of dependence. Psychopharmacology; 142: 369-374.]. Although the mechanism(s) involved in the secondary hypothermic effect of olanzapine are, at present, unclear; the withdrawal hyperthermia observed represents the first report of a clear discontinuation effect of olanzapine. Such discontinuation effects are probably observed with many antipsychotic drugs. Since they have been suggested to facilitate relapse to psychosis and to interfere with subsequent clinical responses to antipsychotics, they merit further detailed analysis in both clinical and preclinical studies.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Progress in Neuro-Psychopharmacology and Biological Psychiatry - Volume 31, Issue 7, 1 October 2007, Pages 1500-1503
Journal: Progress in Neuro-Psychopharmacology and Biological Psychiatry - Volume 31, Issue 7, 1 October 2007, Pages 1500-1503
نویسندگان
Andrew J. Goudie, Jon C. Cole, Harry R. Sumnall,