کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2566574 1128086 2008 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Hybridizing behavioral models: A possible solution to some problems in neurophenotyping research?
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی روانپزشکی بیولوژیکی
پیش نمایش صفحه اول مقاله
Hybridizing behavioral models: A possible solution to some problems in neurophenotyping research?
چکیده انگلیسی

The use of batteries of single-domain tests for neurophenotyping research is a common strategy to achieve higher data density and explore different behavioral domains. This approach, however, is accompanied by several methodological challenges, briefly discussed here. As an alternative, this paper advocates the wider use of extensive “hybrid” protocols that assess multiple domains in parallel, or logically/logistically combine experimental paradigms, in a way that disproportionately maximizes the number of tested phenotypes per experimental manipulation. Several examples of this approach are given in this paper, demonstrating the potential to reduce time, cost and subject requirements for the experiments. Offering behavioral analyses that are lacking in the standard single-domain tests, such “hybrid” models enable innovative modeling of neuropsychiatric disorders by more thorough and broader investigation of complex phenotypical characteristics.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Progress in Neuro-Psychopharmacology and Biological Psychiatry - Volume 32, Issue 5, 1 July 2008, Pages 1172–1178
نویسندگان
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