کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2566695 1561055 2006 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Increased serum levels of glutamate in adult patients with autism
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی روانپزشکی بیولوژیکی
پیش نمایش صفحه اول مقاله
Increased serum levels of glutamate in adult patients with autism
چکیده انگلیسی

BackgroundPrecise mechanisms underlying the pathophysiology of autism are currently unknown. Given the major role of glutamate in brain development, we have hypothesized that glutamatergic neurotransmission plays a role in the pathophysiology of autism. In this study, we studied whether amino acids (glutamate, glutamine, glycine, d-serine, and l-serine) related to glutamatergic neurotransmission are altered in serum of adult patients with autism.MethodsWe measured serum levels of amino acids in 18 male adult patients with autism and age-matched 19 male healthy subjects using high-performance liquid chromatography.ResultsSerum levels (mean = 89.2 μM, S.D. = 21.5) of glutamate in the patients with autism were significantly (t = − 4.48, df = 35, p < 0.001) higher than those (mean = 61.1 μM, S.D. = 16.5) of normal controls. In contrast, serum levels of other amino acids (glutamine, glycine, d-serine, l-serine) in the patients with autism did not differ from those of normal controls. There was a positive correlation (r = 0.523, p = 0.026) between serum glutamate levels and Autism Diagnostic Interview–Revised (ADI-R) social scores in patients.ConclusionsThe present study suggests that an abnormality in glutamatergic neurotransmission may play a role in the pathophysiology of autism.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Progress in Neuro-Psychopharmacology and Biological Psychiatry - Volume 30, Issue 8, 30 December 2006, Pages 1472–1477
نویسندگان
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