کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2569031 | 1128505 | 2012 | 9 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Nonclinical safety strategies for stem cell therapies Nonclinical safety strategies for stem cell therapies](/preview/png/2569031.png)
Recent breakthroughs in stem cell biology, especially the development of the induced pluripotent stem cell techniques, have generated tremendous enthusiasm and efforts to explore the therapeutic potential of stem cells in regenerative medicine. Stem cell therapies are being considered for the treatment of degenerative diseases, inflammatory conditions, cancer and repair of damaged tissue. The safety of a stem cell therapy depends on many factors including the type of cell therapy, the differentiation status and proliferation capacity of the cells, the route of administration, the intended clinical location, long term survival of the product and/or engraftment, the need for repeated administration, the disease to be treated and the age of the population. Understanding the product profile of the intended therapy is crucial to the development of the nonclinical safety study design.
Journal: Toxicology and Applied Pharmacology - Volume 262, Issue 3, 1 August 2012, Pages 223–231