Decreased levels of AKR1B1 and AKR1B10 in cancerous endometrium compared to adjacent non-cancerous tissue

► AKR1B1 and AKR1B10 are implicated in the development of various cancers. ► AKR1B1 expression is decreased in cancerous endometrium of post-menopausal women. ► Higher mRNA and lower protein levels of AKR1B10 are seen in cancerous endometrium. ► In endometrium, AKR1B1 and AKR1B10 appear involved in initiation of carcinogenesis.