Reactivation of organophosphate-inhibited human acetylcholinesterase by isonitrosoacetone (MINA): A kinetic analysis

► We investigated the reactivation kinetics of MINA with OP-inhibited human AChE. ► MINA exhibited an outstanding low affinity but moderate to high reactivity to inhibited AChE. ► These kinetic data indicate that huge MINA concentrations are required for an effective reactivation.