کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2581068 | 1130171 | 2010 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Mechanisms involved in the gastroprotective activity of esculin on acute gastric lesions in mice
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
This work describes the gastroprotective actions of esculin (6,7-dihydroxycoumarin-6-o-glucoside) against indomethacin- or ethanol-induced lesions and verifies the role of nitric oxide, ATP-dependent K+ channels, prostaglandins, transient receptor potential vanilloid 1 and antioxidant effects in the gastroprotective mechanism of esculin in the ethanol-induced gastric lesion model. The intragastric administration of esculin at doses of 12.5, 25 and 50Â mg/kg was able to protect the gastric mucosa against ethanol (0.2Â mL/animal p.o.), and esculin at doses of 25 and 50Â mg/kg protected against indomethacin-induced lesions (20Â mg/kg p.o.). Administration of l-NAME (10Â mg/kg i.p.), glibenclamide (10Â mg/kg i.p.) or indomethacin (10Â mg/kg p.o.), but not capsazepine (5Â mg/kg p.o.), was able to reduce the gastroprotection promoted by esculin (25Â mg/kg) on the ethanol-induced lesions. Measurements of nitrite, a NO metabolite, were increased in the group that was pretreated with esculin. In terms of antioxidant activity as a gastroprotective mechanism of esculin, the results show that pre-treatment with esculin decreased the amount of GSH, increased SOD activity, did not interfere with the CAT activity and decreased both the MPO activity and the MDA amount. In conclusion, pre-treatment with esculin confers significant gastroprotective and antioxidant activity and leads to a reduction in gastric injury; the mechanisms underlying these effects include stimulation of endogenous prostaglandins, nitric oxide synthesis, opening of KATP channels and reduction of free radicals or modulation of antioxidant enzyme systems.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chemico-Biological Interactions - Volume 188, Issue 1, 6 October 2010, Pages 246-254
Journal: Chemico-Biological Interactions - Volume 188, Issue 1, 6 October 2010, Pages 246-254
نویسندگان
Emiliano Ricardo Vasconcelos Rios, Nayrton Flávio Moura Rocha, Edith Teles Venâncio, Brinell Arcanjo Moura, Mariana Lima Feitosa, Gilberto Santos Cerqueira, Pedro Marcos Gomes Soares, David John Woods, Francisca Cléa Florenço de Sousa,