کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2582429 | 1561652 | 2008 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Protective effect of aspartate and glutamate on cardiac mitochondrial function during myocardial infarction in experimental rats
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
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چکیده انگلیسی
The present study investigates the effect of aspartate and glutamate on mitochondrial function during myocardial infarction (MI) in wistar rats. Male albino wistar rats were pretreated with aspartate [100 mg (kg body weight)â1 dayâ1] or glutamate [100 mg (kg body weight)â1 dayâ1] intraperitoneally for a period of 7 days. Following amino acid treatment, MI was induced in rats by subcutaneous injection of isoproterenol [200 mg (kg body weight)â1 dayâ1] for 2 days at an interval of 24 h. Isoproterenol (ISO) induction resulting in significant (P < 0.05) increase in the levels of cardiac mitochondrial lipid peroxidation with a decrease in reduced glutathione level. The activities of glutathione peroxidase and glutathione reductase were significantly (P < 0.05) decreased by ISO. ISO-induction also caused significant (P < 0.05) decrease in the activities of mitochondrial tricarboxylic acid cycle enzymes (malate dehydrogenase, isocitrate dehydrogenase, succinate dehydrogenase, α-ketoglutarate dehydrogenase) and respiratory chain enzymes (NADH dehydrogenase and cytochrome-c-oxidase). ISO significantly (P < 0.05) reduced the cytochrome contents, ATP production, ADP/O ratio and oxidation of succinate in state 3/state 4 whereas significantly (P < 0.05) increased NADH oxidation. Pretreatment with aspartate or glutamate significantly (P < 0.05) reduced the alterations induced by ISO and maintained normal mitochondrial function. The present findings reveal the protective effect of aspartate and glutamate on cardiac mitochondrial function in myocardial infarction-induced rats.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chemico-Biological Interactions - Volume 176, Issues 2â3, 25 November 2008, Pages 227-233
Journal: Chemico-Biological Interactions - Volume 176, Issues 2â3, 25 November 2008, Pages 227-233
نویسندگان
Ramalingam Sivakumar, Pon Velayutham Anandh Babu, Chennam Srinivasulu Shyamaladevi,