کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2582570 1130258 2006 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Oxidative stress related DNA adducts in the liver of female rats fed with sunflower-, rapeseed-, olive- or coconut oil supplemented diets
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
Oxidative stress related DNA adducts in the liver of female rats fed with sunflower-, rapeseed-, olive- or coconut oil supplemented diets
چکیده انگلیسی
Highest adduct levels of etheno-dC (430 ± 181 adducts/109 parent bases), HNE-dGp (617 ± 96 adducts/109 parent bases) and 8-Oxo-dG (37,400 ± 12,200 adducts/109 parent bases) were seen in rats on sunflower oil diet (highest linoleic acid content). Highest adducts levels of etheno-dA (133 ± 113 adducts/109 parent bases) were found in coconut oil diet (lowest content of linoleic acid). Weakly positive correlations between linoleic acid content in the four diet groups were only observed for levels of HNE-dGp and 8-Oxo-dG. Neither the diet based on olive oil (which contains mainly oleic acid) nor the diet based on rapeseed oil (containing α-linolenic acid) exerted any significant protective effect against oxidative DNA damage. Our results indicate that a high linoleic acid diet may contribute to oxidative stress in the liver of female rats leading to a marginal increase in oxidative DNA-damage.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chemico-Biological Interactions - Volume 159, Issue 2, 1 February 2006, Pages 81-89
نویسندگان
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