کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2601972 | 1133354 | 2006 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Differential effects of PCBs on the induction of apoptosis machinery and PKCα translocation in rat renal tubular cell cultures
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Differential effects of PCBs on the induction of apoptosis machinery and PKCα translocation in rat renal tubular cell cultures Differential effects of PCBs on the induction of apoptosis machinery and PKCα translocation in rat renal tubular cell cultures](/preview/png/2601972.png)
چکیده انگلیسی
Aroclor 1248 (a commercial PCB mixture with 48% chlorine by weight), PCB 153 (2,2â²,4,4â²,5,5â²-hexachlorobiphenyl, a di-ortho-substituted nonplanar congener) and PCB 77 (3,3â²,4,4â²-tetrachlorobiphenyl, a non-ortho-substituted planar congener), significantly increased PKCα activity compared to control cells in the cytosolic and particulate cell fractions, and increased the PKCα protein content in the particulate fraction. The nonplanar PCB 153 showed stronger effects than the coplanar congener PCB 77. In addition, Aroclor 1248 decreased both, procaspase-3 levels and the Bcl-2/Bax protein ratio. These findings indicate that PCBs, particularly nonplanar congeners, can induce apoptosis in primary renal tubular cells through the PKCα, caspase-3 and Bcl-2/Bax pathway.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Toxicology Letters - Volume 163, Issue 2, 25 May 2006, Pages 91-100
Journal: Toxicology Letters - Volume 163, Issue 2, 25 May 2006, Pages 91-100
نویسندگان
Mercedes Fernández Santiago, Pedro L. Pérez-Reyes, Pilar López-Aparicio, MarÃa N. Recio, Miguel A. Pérez-Albarsanz,