کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2787908 1154364 2010 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The role of microRNAs in colorectal cancer
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شناسی تکاملی
پیش نمایش صفحه اول مقاله
The role of microRNAs in colorectal cancer
چکیده انگلیسی

MicroRNAs are small non-coding RNAs which regulate gene expression in a post-transcriptional manner. Although the first study was published about 15 years ago, knowledge about their role in regulation of cell proliferation, differentiation, apoptosis and immunity has been greatly advanced recently. Their association with formation, angiogenesis, metastasis and chemotherapy resistance of tumors has become one of the core issues in epigenetics of cancer. Here, we summarize the latest findings concerning microRNAs involved in different signal pathways leading to colorectal cancer, introduce some new potential microRNAs as biomarkers in diagnosis and prognosis, and analyze its application in the treatment of cancer.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Genetics and Genomics - Volume 37, Issue 6, June 2010, Pages 347–358
نویسندگان
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