Effects of Hormone Therapy on Depressive Symptoms and Cognitive Functions in Women With Alzheimer Disease: A 12 Month Randomized, Double-Blind, Placebo-Controlled Study of Low-Dose Estradiol and Norethisterone

HT interacts with ApoE genotype in women with AD. Women without an ApoE ɛ4 allele may get better mood and cognition with HT. HT may reduce depressive mood and give less cognitive decline.