Continuing Treatment of Depression in the Elderly: A Systematic Review and Meta-Analysis of Double-Blinded Randomized Controlled Trials With Antidepressants

Continuing treatment with anti-depressants in elderly patients is efficacious compared with placebo in preventing relapses and recurrences. Efficacy and tolerability during long-term treatment does not differ between TCAs and SSRIs. (Am J Geriatr Psychiatry 2011; 19:249-255)