The Brain-Derived Neurotrophic Factor Val66Met Polymorphism, Hippocampal Volume, and Cognitive Function in Geriatric Depression

Despite different findings in younger populations, the BDNF Val66Met polymorphism is not significantly associated with hippocampal volume or function in a geriatric population. The authors hypothesize that other factors may have a stronger effect on hippocampal structure in older individuals and that the association between the Val66Met polymorphism and geriatric depression is mediated through other mechanisms.