Chlorogenic acid–phospholipid complex improve protection against UVA induced oxidative stress

• Chlorogenic acid–phospholipid complex was prepared for topical delivery.
• The formulation was characterized through HPLC, FTIR, DTA and SEM.
• The topical formulation was evaluated for its UVA protective effect.
• The complex was evaluated for in vitro permeation study.
• The formulation was found to provide sustained UVA protective activity.

The mammalian skin is prone to oxidative damage when exposed to ultraviolet (UV) rays from the sun light. The antioxidants like chlorogenic acid (CA) can protect the skin from the ill effects of UV radiation when applied topically. But conventional topical formulations of these phytomolecules could not protect the skin for long duration owing to their rapid distribution in the systemic circulation. Therefore the aim of the present investigation was to prepare a novel topical formulation of CA which can exert its protective effect for long time after its application. The phospholipid complex of the CA was prepared and evaluated against oxidative stress produced in the rat skin due to UVA exposure. Compared to the conventional formulation, the complex exerted improved protection when UVA irradiation was performed after 4 h of topical application. Thus the results ascertain the superiority of CA–phospholipid complex over conventional formulation in terms of protection against UVA radiation for long duration.

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