کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
30513 | 44483 | 2012 | 8 صفحه PDF | دانلود رایگان |
Chlorin-based photosensitizers in photodynamic therapy are the promising anticancer agents, but some of their properties such as specific-targeting to tumor need to be improved. The aim of this study was to synthesize chlorin-based unsaturated fatty acid conjugates to obtain an optimal photosensitizers. Thus four chlorin-based fatty acid conjugates were successfully synthesized through an esterification reaction using carbodiimide coupling reagents in enough yields. Then, structures of these conjugates were confirmed by 1H NMR, MALDI-MS, and UV–vis spectroscopy. Furthermore, their in vitro phototoxicity and cellular uptake were evaluated on TC-1 lung cancer cell line and HeLa cell line.
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► Four unsaturated fatty acid conjugates were synthesized for photodynamic therapy.
► Phototoxicity of PDT conjugates was evaluated with TC-1 cell line via MTT assay.
► PDT conjugates cellular uptake was investigated with TC-1 cell line.
Journal: Journal of Photochemistry and Photobiology B: Biology - Volume 110, 2 May 2012, Pages 50–57