کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
30513 44483 2012 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis of chlorin-based unsaturated fatty acid conjugates: Their in vitro phototoxicity on TC-1 cancer cell line
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی بیو مهندسی (مهندسی زیستی)
پیش نمایش صفحه اول مقاله
Synthesis of chlorin-based unsaturated fatty acid conjugates: Their in vitro phototoxicity on TC-1 cancer cell line
چکیده انگلیسی

Chlorin-based photosensitizers in photodynamic therapy are the promising anticancer agents, but some of their properties such as specific-targeting to tumor need to be improved. The aim of this study was to synthesize chlorin-based unsaturated fatty acid conjugates to obtain an optimal photosensitizers. Thus four chlorin-based fatty acid conjugates were successfully synthesized through an esterification reaction using carbodiimide coupling reagents in enough yields. Then, structures of these conjugates were confirmed by 1H NMR, MALDI-MS, and UV–vis spectroscopy. Furthermore, their in vitro phototoxicity and cellular uptake were evaluated on TC-1 lung cancer cell line and HeLa cell line.

Figure optionsDownload as PowerPoint slideHighlights
► Four unsaturated fatty acid conjugates were synthesized for photodynamic therapy.
► Phototoxicity of PDT conjugates was evaluated with TC-1 cell line via MTT assay.
► PDT conjugates cellular uptake was investigated with TC-1 cell line.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Photochemistry and Photobiology B: Biology - Volume 110, 2 May 2012, Pages 50–57
نویسندگان
, , , , , , ,