کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3056785 | 1580196 | 2008 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Growth dynamics and morphology of regenerating optic fibers in tectum are altered by injury conditions: An in vivo imaging study in goldfish
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کلمات کلیدی
WGA-HRPBDNF - BDNF یا فاکتور نورونزایی مشتقشده از مغز axon - آکسون Regeneration - باززاییTopography - توپوگرافیTectum - سقفRetina - شبکیهBrain-derived neurotrophic factor - فاکتور نوروتروفی مشتق شده از مغزPlasticity - پلاستیکwheat germ agglutinin-horseradish peroxidase - گیاه گندم آگلوتیینین-هورسادید پراکسیداز
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
عصب شناسی
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
The dynamic behavior of axons in systems that normally regenerate may provide clues for promoting regeneration in humans. When the optic nerve is severed in adult goldfish, all axons regenerate back to the tectum to reestablish accurate connections. In adult mammals, regeneration can be induced in optic and other axons but typically few fibers regrow and only for short distances. These conditions were mimicked in the adult goldfish by surgically deflecting 10-20% of optic fibers from one tectum into the opposite tectum which was denervated of all other optic fibers by removing its corresponding eye. At 21-63Â days, DiI was microinjected into retina to label a few fibers and the fibers were visualized in the living fish for up to 5-7Â h. The dynamic behavior and morphology of these regenerating deflected fibers were analyzed and compared to those regenerating following optic nerve crush. At 3-4Â weeks, deflected fibers were found to form more branches and to maintain many more branches than crushed fibers. Although both deflected and crushed fibers exhibited stochastic growth and retraction, deflected fibers spent more time growing but grew for less distance. At 2Â months, both deflected and crushed fibers became much more stable. These results show that the morphology and behavior of fibers regenerating into the same target tissue can be substantially altered by the injury conditions, that is, they show state-dependent plasticity. The morphology and behavior of the deflected fibers suggest they were impaired in their capacity to grow to their correct targets.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental Neurology - Volume 210, Issue 2, April 2008, Pages 592-601
Journal: Experimental Neurology - Volume 210, Issue 2, April 2008, Pages 592-601
نویسندگان
Amy J. Dawson, Ronald L. Meyer,