کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
31007 44528 2010 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Probing oxidative stress in single erythrocytes with Raman Tweezers
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی بیو مهندسی (مهندسی زیستی)
پیش نمایش صفحه اول مقاله
Probing oxidative stress in single erythrocytes with Raman Tweezers
چکیده انگلیسی

Raman Tweezers have been successfully applied to characterize chemically-induced oxidative stress on optically-trapped live, single erythrocytes. There is significant enhancement in Raman peak intensities corresponding to SS and C–S stretching modes that are induced by oxidative stress. This is consistent with the formation of mixed disulphides between protein SH groups and low-molecular-mass thiols such as glutathione during oxidative damage to cells. Enhancement in glutathione level as a protective response against oxidative stress has been observed. Principal component analysis of the data yields good discrimination between spectra of normal and stress-induced red blood cells.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Photochemistry and Photobiology B: Biology - Volume 100, Issue 3, 2 September 2010, Pages 113–116
نویسندگان
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