کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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3120909 | 1583317 | 2013 | 7 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Induction of immune response and prevention of alveolar bone loss with recombinant Porphyromonas gingivalis peptidylarginine deiminase Induction of immune response and prevention of alveolar bone loss with recombinant Porphyromonas gingivalis peptidylarginine deiminase](/preview/png/3120909.png)
ObjectiveTreatments for periodontitis are not absolutely perfect, and a vaccine against Porphyromonas gingivalis (P. gingivalis) could become a valuable adjunct therapy for periodontitis.DesignIn this study, a vaccine of peptidylarginine deiminase (PAD) from P. gingivalis was evaluated in P. gingivalis-induced murine lesion and periodontitis models. The prevention of alveolar bone loss analysis determined by micro-computed X-ray tomography (micro-CT), and histological assays. Furthermore, the induction of immune response of mouse anti-PAD done with ELISA and Western Blot analysis.ResultsCompared with animal immunization with incomplete Freund's adjuvant (IFA) alone, PAD group significantly inhibited (P < 0.05) bone resorption. ELISA and Western Blot showed that PAD induced response involving immunoglobulin G1 (Ig G1) predominantly.ConclusionsThese results suggest that PAD could be a candidate antigen for a vaccine against P. gingivalis infection.
Journal: Archives of Oral Biology - Volume 58, Issue 12, December 2013, Pages 1777–1783