کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3121082 1583321 2013 18 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Gene clustering analysis in human osteoporosis disease and modifications of the jawbone
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی دندانپزشکی، جراحی دهان و پزشکی
پیش نمایش صفحه اول مقاله
Gene clustering analysis in human osteoporosis disease and modifications of the jawbone
چکیده انگلیسی

ObjectiveAn analysis of the genes involved in both osteoporosis and modifications of the jawbone, through text mining, using a web search tool, of information regarding gene/protein interaction.DesignThe final set of genes involved in the present phenomenon was obtained by expansion-filtering loop. Using a web-available software (STRING), interactions among all genes were searched for, and a clustering procedure was performed in which only high-confidence predicted associations were considered.ResultsTwo hundred forty-two genes potentially involved in osteoporosis and in modifications of the jawbone were recorded. Seven “leader genes” were identified (CTNNB1, IL1B, IL6, JUN, RUNX2, SPP1, TGFB1), while another 10 genes formed the cluster B group (BMP2, BMP7, COL1A1, ICAM1, IGF1, IL10, MMP9, NFKB1, TNFSF11, VEGFA). Ninety-eight genes had no interactions, and were defined as “orphan genes”.ConclusionsThe expansion of knowledge regarding the molecular basis causing osteoporotic traits has been brought about with the help of a de novo identification, based on the data mining of genes involved in osteoporosis and in modification of the jawbone. A comparison of the present data, in which no role was verified for 98 genes that had been previously supposed to have a role, with that of the literature, in which another 81 genes, as obtained from GWAS reviews and meta-analyses, appeared to be strongly associated with osteoporosis, probably attests to a lack of information on osteoporotic disease.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Archives of Oral Biology - Volume 58, Issue 8, August 2013, Pages 912–929
نویسندگان
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