کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
315534 1432602 2013 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Evolutionary genetic analyses of MEF2C gene: Implications for learning and memory in Homo sapiens
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Evolutionary genetic analyses of MEF2C gene: Implications for learning and memory in Homo sapiens
چکیده انگلیسی

MEF2C facilitates context-dependent fear conditioning (CFC) which is a salient aspect of hippocampus-dependent learning and memory. CFC might have played a crucial role in human evolution because of its advantageous influence on survival of species. In this study, we analyzed 23 orthologous mammalian gene sequences of MEF2C gene to examine the evidence for positive selection on this gene in Homo sapiens using Phylogenetic Analysis by Maximum Likelihood (PAML) and HyPhy software. Both PAML Bayes Empirical Bayes (BEB) and HyPhy Fixed Effects Likelihood (FEL) analyses supported significant positive selection on 4 codon sites in H. sapiens. Also, haplotter analysis revealed significant ongoing positive selection on this gene in Central European population. The study findings suggest that adaptive selective pressure on this gene might have influenced human evolution. Further research on this gene might unravel the potential role of this gene in learning and memory as well as its pathogenetic effect in certain hippocampal disorders with evolutionary basis like schizophrenia.


► MEF2C gene facilitates context-dependent fear conditioning which is a salient aspect of hippocampus-dependent learning and memory.
► Evolutionary genetic analyses suggest that adaptive selective pressure on this gene might have influenced human evolution.
► Further research studies on MEF2C gene might unravel evolutionarily informed theories on hippocampus dependent disorders.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Asian Journal of Psychiatry - Volume 6, Issue 1, February 2013, Pages 56–59
نویسندگان
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