کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3189463 1201012 2008 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Affections inflammatoires à médiation immunitaire et psoriasis
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی امراض پوستی
پیش نمایش صفحه اول مقاله
Affections inflammatoires à médiation immunitaire et psoriasis
چکیده انگلیسی
The association of some immune-mediated inflammatory disease in a same patient is known. Nevertheless, this is difficult to appreciate practically for the psoriasis due to the absence of prospective study. The strongest link is with Crohn's disease and the spondyloartropathies. It is sustained by, i) genetic data obtained by genome-wide association study showing some common loci and/or genes involved in innate immunity, ii) immunologic data, these conditions sharing effector cells among which Th17 lymphocytes and inflammatory mediators (TNF-α, IL-1,17,23…), that explain the related efficacy of some biologics like anti-TNF-α, IL-12/23 antibody and others in progress and iii) environmental triggers among which bacterial infections are probably determining in the genesis of these diseases even if this is still only an hypothesis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Annales de Dermatologie et de Vénéréologie - Volume 135, Supplement 4, February 2008, Pages 269-274
نویسندگان
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