Relationships of methacholine and adenosine monophosphate responsiveness with serum vascular endothelial growth factor in children with asthma

Serum VEGF levels were increased in children with asthma and were related to airway responsiveness to AMP but not to methacholine. Increased VEGF levels in asthmatic children may result in increased airway responsiveness by mechanisms related to airway inflammation or increased permeability of airway vasculature.