Direct and indirect challenges in the clinical assessment of asthma

Direct challenges (ie, methacholine), because of the high sensitivity, function best to exclude clinically current asthma; a positive test result is consistent with but not diagnostic of asthma. By contrast, indirect challenges are superior for confirming asthma and are the challenges of choice when exercise bronchospasm is the question (eg, certification for international athletic competition, armed forces, scuba diving). Indirect challenges would be preferred for monitoring of asthma control and used serially to help diagnose occupational asthma.