کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3204764 1587525 2015 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Atypical manifestations of graft-versus-host disease
ترجمه فارسی عنوان
تظاهر غیرمعمول بیماری گرافت در برابر میزبان
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی امراض پوستی
چکیده انگلیسی

BackgroundCutaneous graft-versus-host disease (GVHD) is classically described as morbilliform when acute and lichen planus–like or sclerotic when chronic. In addition to these well-known clinical forms, there are many other presentations of GVHD that are important to recognize. As the number of patients undergoing stem cell transplantation increases and the survival after transplantation improves, the prevalence of GVHD is expected to rise, and its various presentations will be increasingly encountered in clinical practice.ObjectiveWe sought to report unusual manifestations of skin GVHD and provide a summary of typical and atypical presentations of GVHD reported in the literature.MethodsPatients with stem cell transplantation who developed unusual eruptions after transplantation had biopsy specimens taken to evaluate for histopathologic evidence of GVHD.ResultsSix patients presented with unusual cases of biopsy-proven GVHD, including follicular hyperkeratosis, thick-appearing white tongue, inverse pityriasis rosea–like, and eczema craquelé–like GVHD.LimitationsThis study is limited by case number.ConclusionsBecause of the high rate of cutaneous involvement with GVHD, the accessibility of the skin for diagnosis, and the morbidity associated with severe or long-standing skin involvement, it is important for dermatologists to recognize and accurately diagnose cutaneous GVHD in all its protean manifestations.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of the American Academy of Dermatology - Volume 72, Issue 4, April 2015, Pages 690–695
نویسندگان
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