کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3205074 1587523 2015 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A clinical, histopathologic, and outcome study of melanonychia striata in childhood
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی امراض پوستی
پیش نمایش صفحه اول مقاله
A clinical, histopathologic, and outcome study of melanonychia striata in childhood
چکیده انگلیسی

BackgroundThe current literature suggests that approximately 5% to 10% of melanonychia striata cases in adults are the result of subungual melanoma.ObjectiveWe sought to evaluate the clinical and histopathologic features and to determine the outcomes and causes of melanonychia striata in a cohort of children.MethodsWe assessed 30 childhood cases of melanonychia striata for features typically associated with melanoma such as Hutchinson sign, width of the pigmented band, evolution, color, and nail dystrophy. We assessed the histopathology of lesional biopsy specimens, including melanocyte counts and suprabasal movement of melanocytes. Clinical follow-up information was reviewed when available.ResultsHistopathologic diagnoses included subungual lentigo in 20 cases, subungual nevus in 5 cases, and atypical melanocytic hyperplasia in 5 cases. Although a number of cases exhibited worrisome clinical or histopathologic features, none showed evidence of aggressive behavior or warranted a diagnosis of melanoma.LimitationsThe sample size and follow-up times are limited.ConclusionsMelanonychia striata is typically associated with benign stable melanocytic proliferations in childhood. The overwhelming majority of cases can be managed conservatively. Biopsy is required in select cases.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of the American Academy of Dermatology - Volume 72, Issue 5, May 2015, Pages 773–779
نویسندگان
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