کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3207330 1587582 2011 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Therapeutic ladder for pemphigus vulgaris: Emphasis on achieving complete remission
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی امراض پوستی
پیش نمایش صفحه اول مقاله
Therapeutic ladder for pemphigus vulgaris: Emphasis on achieving complete remission
چکیده انگلیسی

BackgroundPemphigus vulgaris (PV) is a blistering autoimmune bullous disease that is usually fatal without proper treatment. There are no clear treatment guidelines for PV at this time.PurposeWe suggest a standard treatment regimen for patients with PV based on the success of our treatment.MethodsA retrospective chart review of 18 patients with PV was conducted to assess response to a similar approach using mycophenolate mofetil (MMF) and prednisone. Diagnosis was confirmed through routine histology, direct immunofluorescence, and indirect immunofluorescence, and patients were followed up for a total average of 35.2 months.ResultsWe achieved complete disease control in 89% of patients using our treatment algorithm. Fourteen of 18 patients achieved complete disease control on therapy with prednisone and MMF. Three of the 4 patients who did not achieve control on MMF and prednisone went on to receive rituximab therapy, and two of those patients achieved disease control on rituximab. The average length of time from initiating therapy to 75% clearance of lesions was 4.5 months. Three of 18 patients were able to discontinue therapy after an average of 3 years and have remained in complete remission for more than 1 year.LimitationsThis was a retrospective chart review with a small patient sample size.ConclusionsThe combination therapy of MMF and prednisone is an effective treatment regimen to achieve rapid and complete control of PV. For those patients who fail treatment with MMF and prednisone, rituximab is an efficacious alternative therapy.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of the American Academy of Dermatology - Volume 64, Issue 3, March 2011, Pages 490–494
نویسندگان
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