کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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3208334 | 1587591 | 2010 | 8 صفحه PDF | دانلود رایگان |

BackgroundPatients with tuberous sclerosis complex (TSC) are predisposed to developing ungual fibromas and other acral lesions.ObjectiveWe sought to determine the numbers, types, and locations of acral skin lesions in TSC.MethodsWe examined and photographed 76 adult women with TSC.ResultsThe age of the patients ranged from 20 to 69 years, with a mean age of 39 ± 11 years. Ungual fibromas were observed in 61 of 76 patients (80%). Periungual fibromas were more common than subungual fibromas, were more common on the feet than the hands, and showed the greatest frequency on the fifth toe. Longitudinal grooves in the nails occurred with or without a visible fibroma. Longitudinal short red streaks–lesions that we term “red comets”–were observed in 22 patients (29%). Longitudinal leukonychia was observed in 14 patients (18%). One patient had isolated digital overgrowth and one patient had pachydermodactyly.LimitationsNo men or children were included in this study.ConclusionsExamination of patients for skin lesions of TSC could be improved by including inspection for longitudinal nail grooves, red comets, longitudinal leukonychia, and splinter hemorrhages in addition to ungual fibromas. The anatomic distribution of TSC ungual fibromas is not random and appears consistent with trauma-promoted tumor formation.
Journal: Journal of the American Academy of Dermatology - Volume 63, Issue 2, August 2010, Pages 244–251