کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3208736 | 1587618 | 2008 | 8 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Topical methyl-aminolevulinate photodynamic therapy using red light-emitting diode light for treatment of multiple actinic keratoses: A randomized, double-blind, placebo-controlled study Topical methyl-aminolevulinate photodynamic therapy using red light-emitting diode light for treatment of multiple actinic keratoses: A randomized, double-blind, placebo-controlled study](/preview/png/3208736.png)
BackgroundThe use of light-emitting diode light offers practical advantages in photodynamic therapy (PDT) with topical methyl-aminolevulinate (MAL) for management of actinic keratoses (AK).ObjectiveWe sought to evaluate the efficacy of MAL PDT using red light-emitting diode light.MethodsWe conducted a multicenter, double-blind, randomized study. A total of 49 patients with 363 AK lesions had 16.8% MAL cream applied under occlusion for 3 hours, and 47 patients with 360 AK lesions had vehicle cream similarly applied. The lesions were then illuminated (630 nm, light dose 37 J/cm2) with repeated treatment 1 week later. Complete lesion and patient (all lesions showing complete response) response rates were evaluated 3 months after last treatment.ResultsMAL PDT was superior (P < .0001) to vehicle PDT with respect to lesion complete response (86.2% vs 52.2%, odds ratio 6.9 [95% confidence interval 4.7-10.3]) and patient complete response (59.2% vs 14.9%, odds ratio 13.2 [95% confidence interval 4.1-43.1]).LimitationsThe study population may not be representative of all patients with AK.ConclusionMAL PDT using red light-emitting diode light is an appropriate treatment alternative for multiple AK lesions.
Journal: Journal of the American Academy of Dermatology - Volume 59, Issue 4, October 2008, Pages 569–576