کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3208848 1587588 2010 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Progressive overgrowth of the cerebriform connective tissue nevus in patients with Proteus syndrome
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی امراض پوستی
پیش نمایش صفحه اول مقاله
Progressive overgrowth of the cerebriform connective tissue nevus in patients with Proteus syndrome
چکیده انگلیسی

BackgroundProteus syndrome is a rare overgrowth disorder that almost always affects the skin.ObjectiveOur purpose was to evaluate progression of skin lesions in patients with Proteus syndrome.MethodsSkin findings were documented in 36 patients with Proteus syndrome. Progression of skin lesions in 16 of these patients was assessed by comparing photographs obtained on repeated visits for an average total duration of 53 months.ResultsThe skin lesion most characteristic of Proteus syndrome, the cerebriform connective tissue nevus, showed progression in 13 children but not in 3 adults. The cerebriform connective tissue nevus progressed by expansion into previously uninvolved skin, increased thickness, and development of new lesions. Lipomas increased in size, number, or both in 8 of 10 children with lipomas. In contrast, epidermal nevi and vascular malformations generally did not spread or increase in number.LimitationsOnly 3 adults with Proteus syndrome were evaluated longitudinally.ConclusionThe cerebriform connective tissue nevus in Proteus syndrome grows throughout childhood but tends to remain stable in adulthood.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of the American Academy of Dermatology - Volume 63, Issue 5, November 2010, Pages 799–804
نویسندگان
, , , ,