کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3209112 1587602 2009 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A prospective randomized trial of topical pimecrolimus for cetuximab-associated acne-like eruption
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی امراض پوستی
پیش نمایش صفحه اول مقاله
A prospective randomized trial of topical pimecrolimus for cetuximab-associated acne-like eruption
چکیده انگلیسی

BackgroundClinical trials addressing the acneiform rash associated with epidermal growth factor receptor inhibitors are lacking.ObjectiveWe evaluated the ability of topical pimecrolimus to reduce the severity of cetuximab-related facial rash.MethodsIn all, 24 patients with metastatic colorectal cancer with cetuximab facial rash received twice daily pimecrolimus application for 5 weeks to half of the face. At baseline, week 2, and week 5, a dermatologist performed facial lesion counts, patients reported perceived severity of rash-related symptoms, and standardized facial photographs were obtained for blinded evaluation of global rash severity.ResultsTreatment sides had greater decrease in lesion counts than observation sides of face at weeks 2 (P < .001) and 5 (P = .02). However, there were no significant differences in patients' assessment of symptoms and in review of facial photographs for rash severity between treatment and observation sides.LimitationsThis study was not placebo controlled.ConclusionsPimecrolimus application did not translate into clinically meaningful benefit for patients with cetuximab-related facial rash.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of the American Academy of Dermatology - Volume 61, Issue 4, October 2009, Pages 614–620
نویسندگان
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